3 ms·

Researchers are racing to determine whether a fast-spreading variant in South Africa poses a threat to COVID vaccines’ effectiveness.

Taniwha 5y ago
I don't think we even know that it's "fast spreading" yet. It's just different enough to have set off various scientist's personal danger detectors. The thing is that mutations probably occur all the time, most don't provide any evolutionary advantage and probably never get passed on, the fact that something with this many mutations being viable is a bit worrying - equally I think that the evolutionary pressure that vaccines represent is going to result in mutations that work better in vaccinated people - and as a result we'll make better vaccines - one of the great things about mRNA vaccines is that we can knock out new ones really quickly
- jb1991 5y ago
  > I don't think we even know that it's "fast spreading" yet. We do know: > A new coronavirus variant has been detected in South Africa that scientists say is a concern because of its high number of mutations and rapid spread among young people in Gauteng, the country’s most populous province. “Over the last four or five days, there has been more of an exponential rise,” he said, adding that the new variant appears to be driving the spike in cases. “We can see that the variant is potentially spreading very fast. We do expect to start seeing pressure in the healthcare system in the next few days and weeks.” https://abcnews.go.com/Health/wireStory/south-african-scientists-detect-virus-variant-amid-spike-81397494 https://abcnews.go.com/Health/wireStory/south-african-scient...
- cromka 5y ago
  https://twitter.com/miamalan/status/1463846542264131584 https://twitter.com/miamalan/status/1463846542264131584
- erhk 5y ago
  Every sequence is distinct almost certainly. It just matters if the important parts of a sequence are changed or duplicated. So two versions which are sequenced as a certain variant may actually have many differences in practice. I will also add that there are many variants that just havent hit the news cycle. Iirc there was a gamma variant with higher lethality but was much less transmissible.
zamalek 5y ago
My [numerous] friends in South Africa say that anti-vax superstition is extremely common, and current vaccine participation is purely based on fear (everyone who agrees with science has been vaccinated). The variant may well be ravaging the unvaccinated alone. Of course, you're right, the unvaccinated are a fertile ground for mutations that eventually evade the vaccine.
- makomk 5y ago
  Yeah, South Africa apparently postponed their upcoming vaccine deliveries recently because they're running out of willing people to vaccinate and the current stockpiles will last half a year at the current rate: https://www.reuters.com/world/africa/exclusive-south-africa-delays-covid-vaccine-deliveries-inoculations-slow-2021-11-24/ https://www.reuters.com/world/africa/exclusive-south-africa-...
- didjathinkmess 5y ago
  Good comment, also: the vaccinated are a fertile ground for mutations that eventually evade the vaccine. Unless you have a study that backs up the claim that this mutation phenomenon only happens in people not vaccinated for Covid-19, you should probably stop singling them out. The phenomenon occurs in both.
  - Robotbeat 5y ago
    Those who have already had COVID are fertile ground for a variant evades the immune response from previous exposure.
  - frankzinger 5y ago
    The virus spreads more rapidly among and lives for longer inside the unvaccinated, as a result getting much more exposure to human immune systems, and thus giving it more opportunity to evolve.
ukie 5y ago
Eventually, there'll be an immune escape variant killing vaccines like crazy, but for now, it's all media driven fear. Ignore.
tomjen3 5y ago
I wish we could delay the news until we knew basic facts like that. If there is a new variant I really don't care unless it is likely to get past my vaccine, and is dangerous.

Taniwha 5y ago

I don't think we even know that it's "fast spreading" yet. It's just different enough to have set off various scientist's personal danger detectors. The thing is that mutations probably occur all the time, most don't provide any evolutionary advantage and probably never get passed on, the fact that something with this many mutations being viable is a bit worrying - equally I think that the evolutionary pressure that vaccines represent is going to result in mutations that work better in vaccinated people - and as a result we'll make better vaccines - one of the great things about mRNA vaccines is that we can knock out new ones really quickly

jb1991 5y ago
> I don't think we even know that it's "fast spreading" yet. We do know: > A new coronavirus variant has been detected in South Africa that scientists say is a concern because of its high number of mutations and rapid spread among young people in Gauteng, the country’s most populous province. “Over the last four or five days, there has been more of an exponential rise,” he said, adding that the new variant appears to be driving the spike in cases. “We can see that the variant is potentially spreading very fast. We do expect to start seeing pressure in the healthcare system in the next few days and weeks.” https://abcnews.go.com/Health/wireStory/south-african-scientists-detect-virus-variant-amid-spike-81397494 https://abcnews.go.com/Health/wireStory/south-african-scient...
cromka 5y ago
https://twitter.com/miamalan/status/1463846542264131584 https://twitter.com/miamalan/status/1463846542264131584
erhk 5y ago
Every sequence is distinct almost certainly. It just matters if the important parts of a sequence are changed or duplicated. So two versions which are sequenced as a certain variant may actually have many differences in practice. I will also add that there are many variants that just havent hit the news cycle. Iirc there was a gamma variant with higher lethality but was much less transmissible.

zamalek 5y ago

My [numerous] friends in South Africa say that anti-vax superstition is extremely common, and current vaccine participation is purely based on fear (everyone who agrees with science has been vaccinated). The variant may well be ravaging the unvaccinated alone. Of course, you're right, the unvaccinated are a fertile ground for mutations that eventually evade the vaccine.

makomk 5y ago
Yeah, South Africa apparently postponed their upcoming vaccine deliveries recently because they're running out of willing people to vaccinate and the current stockpiles will last half a year at the current rate: https://www.reuters.com/world/africa/exclusive-south-africa-delays-covid-vaccine-deliveries-inoculations-slow-2021-11-24/ https://www.reuters.com/world/africa/exclusive-south-africa-...
didjathinkmess 5y ago
Good comment, also: the vaccinated are a fertile ground for mutations that eventually evade the vaccine. Unless you have a study that backs up the claim that this mutation phenomenon only happens in people not vaccinated for Covid-19, you should probably stop singling them out. The phenomenon occurs in both.
- Robotbeat 5y ago
  Those who have already had COVID are fertile ground for a variant evades the immune response from previous exposure.
- frankzinger 5y ago
  The virus spreads more rapidly among and lives for longer inside the unvaccinated, as a result getting much more exposure to human immune systems, and thus giving it more opportunity to evolve.

ukie 5y ago

Eventually, there'll be an immune escape variant killing vaccines like crazy, but for now, it's all media driven fear. Ignore.

tomjen3 5y ago

I wish we could delay the news until we knew basic facts like that. If there is a new variant I really don't care unless it is likely to get past my vaccine, and is dangerous.