> (is it just waning antibody concentration?) Two notable mechanisms: * The booster shot does increase antibody concentrations and recruits more memory B cel

> (is it just waning antibody concentration?) Two notable mechanisms: * The booster shot does increase antibody concentrations and recruits more memory B cells to make antibodies. * Each booster also significantly increases the diversity of the immune response. You get more antibodies against the antigen, and you also get many more antibodies against things kind of like the antigen. > but what is the long term strategy here? Is there going to be annual boosters That's a really good question. I personally believe (based on little evidence at this time) that each dose provides some small permanent increase in protection against infection, and a somewhat larger permanent increase in protection against severe illness. So as we go through this whole exercise, a greater proportion of the population is protected and people are less likely to be carriers. In turn, it becomes easier to leave things up to individual choice, as the overall baseline risk reduces and people's choice mostly affects their own health. > and I think it is time now that things are under relative control to start having adult discussions and public policy debates once more. Yes. Look, I don't want to wear masks forever indoors. I think it'd be great to normalize it for when we're feeling under the weather or it's flu season, but I also want to be able to see other peoples' faces and carry on normal conversations.