5 ms·

Isn't their data also showing that Moderna is the most effective vaccine at preventing deaths?

by rllearneratwork 5y ago

GuB-42 5y ago
Moderna seems to be slightly more effective but with slightly worse side effects. Dose is the most likely explanation (30µg for Pfizer/Biontech vs 100µg for Moderna).
- less_less 5y ago
  An additional reason is that Pfizer/Biontech was available first, so old or otherwise vulnerable people are more likely to have been vaccinated with that. That is, Moderna is probably more effective, but people vaccinated with it have an even lower death rate because they're less likely to have been in a vulnerable group. This is also a major factor that can be missed when going over the vaxxed vs unvaxxed death rates. If (eg) 75% of the population is vaxxed, 5% chose not to take it and 20% are too young (and thus very unlikely to die of Covid), then the difference in death rate will be much smaller than you'd expect based on vaccine effectiveness.
anonporridge 5y ago
I believe that's been the growing consensus for a while now.
- Pyramus 5y ago
  Yes, and we are also pretty certain that the mechanism of action is the number of mRNA particles contained: 30 µg for Pfizer/Biontech vs 100 µg for Moderna. As a result, Germany e.g. uses half-doses for Moderna and vaccinates under 30s exclusively with Biontech.
  - pfg 5y ago
    Just to clarify: half-doses are only used for booster shots (following EMA recommendation). First and second shots still use full dosage.
    - Pyramus 5y ago
      That is correct, thanks for clarifying.
jjcon 5y ago
I believe that has been established for a while now across multiple jurisdictions. Most approved vaccines in eu and us are quite effective though https://www.usnews.com/news/health-news/articles/2021-09-17/cdc-moderna-vaccine-the-most-effective-at-preventing-hospitalization https://www.usnews.com/news/health-news/articles/2021-09-17/...

5 ms·

Isn't their data also showing that Moderna is the most effective vaccine at preventing deaths?

by rllearneratwork 5y ago

Isn't their data also showing that Moderna is the most effective vaccine at preventing deaths?

GuB-42 5y ago
Moderna seems to be slightly more effective but with slightly worse side effects. Dose is the most likely explanation (30µg for Pfizer/Biontech vs 100µg for Moderna).
- less_less 5y ago
  An additional reason is that Pfizer/Biontech was available first, so old or otherwise vulnerable people are more likely to have been vaccinated with that. That is, Moderna is probably more effective, but people vaccinated with it have an even lower death rate because they're less likely to have been in a vulnerable group. This is also a major factor that can be missed when going over the vaxxed vs unvaxxed death rates. If (eg) 75% of the population is vaxxed, 5% chose not to take it and 20% are too young (and thus very unlikely to die of Covid), then the difference in death rate will be much smaller than you'd expect based on vaccine effectiveness.
anonporridge 5y ago
I believe that's been the growing consensus for a while now.
- Pyramus 5y ago
  Yes, and we are also pretty certain that the mechanism of action is the number of mRNA particles contained: 30 µg for Pfizer/Biontech vs 100 µg for Moderna. As a result, Germany e.g. uses half-doses for Moderna and vaccinates under 30s exclusively with Biontech.
  - pfg 5y ago
    Just to clarify: half-doses are only used for booster shots (following EMA recommendation). First and second shots still use full dosage.
    - Pyramus 5y ago
      That is correct, thanks for clarifying.
jjcon 5y ago
I believe that has been established for a while now across multiple jurisdictions. Most approved vaccines in eu and us are quite effective though https://www.usnews.com/news/health-news/articles/2021-09-17/cdc-moderna-vaccine-the-most-effective-at-preventing-hospitalization https://www.usnews.com/news/health-news/articles/2021-09-17/...