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I thought the main point of mouse models was mostly to be a "first pass filter" for substances before moving onto other animals usually, sometimes humans if the

I thought the main point of mouse models was mostly to be a "first pass filter" for substances before moving onto other animals usually, sometimes humans if the straits are desperate enough. Cancer drugs in particular have little concern for long term side effects in their approval pipeline because the alternative may be having no long term.

ekianjo 5y ago
First pass filters mean nothing when it comes to humans. 95% of all "stuff that works on mice" fails miserably on humans. We should treat such announcements with extreme skepticism.