5 ms·
Yes, as a logical first step. Now we at least have hope this might work for humans.
by MrDresden 5y ago
Yes, as a logical first step.
Now we at least have hope this might work for humans.
- ekianjo 5y agoMice models have a very bad track record when it comes to humans. Too much junk publications out there to push papers and get credits.
- hungryforcodes 5y agoYou have to start somewhere though.
- jonplackett 5y agoI would guess things like how nerves and bones work is more similar across species than, say, how drugs might work on the brain, where a mouse brain is a hell of a lot different to human. Is that a reasonable assumption?
- AnthonBerg 5y agoIf there is a difference, we’ll learn what the difference is, and if there’s another one after that the same, and so on.
- hungryforcodes 5y agoRight, exactly! You expressed it much better than I did. :)
- Kaibeezy 5y agoI was wondering the same thing. Pluses and minuses... Rodents represent readily available models that can be used for a deeper understanding of basic biological mechanisms and for proof of concept for preclinical research hypotheses. However, attempts at direct clinical translation to humans have proven problematic or even impossible to date, principally due to issues of scaling and complexity. https://clinmedjournals.org/articles/ijscrt/international-journal-of-stem-cell-research-and-therapy-ijscrt-3-042.php?jid=ijscrt https://clinmedjournals.org/articles/ijscrt/international-jo...
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- Chris2048 5y agoYes, but publication of hopeful articles should be near the end, not the start.
- Nasrudith 5y agoI thought the main point of mouse models was mostly to be a "first pass filter" for substances before moving onto other animals usually, sometimes humans if the straits are desperate enough. Cancer drugs in particular have little concern for long term side effects in their approval pipeline because the alternative may be having no long term.
- ekianjo 5y agoFirst pass filters mean nothing when it comes to humans. 95% of all "stuff that works on mice" fails miserably on humans. We should treat such announcements with extreme skepticism.