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The WHO agrees: Does it prevent infection and transmission? There is currently no substantive data are available related to impact of Pfizer BioNTech vac

by Capira 5y ago

The WHO agrees: Does it prevent infection and transmission? There is currently no substantive data are available related to impact of Pfizer BioNTech vaccine on transmission or viral shedding. https://www.who.int/news-room/feature-stories/detail/who-can-take-the-pfizer-biontech-covid-19--vaccine https://www.who.int/news-room/feature-stories/detail/who-can...

eqvinox 5y ago
The WHO agrees on "transmission or viral shedding". The WHO disagrees if anyone's tries to claim the vaccine doesn't help. The Pfizer BioNTech vaccine against COVID-19 has an efficacy of 95% against symptomatic SARS-CoV-2 infection. And each and every ICU bed taken up by an unvaccinated SARS-CoV-2 case taking a severe turn is an ICU bed that, with above 95% probability (yes, naïvely), could've been available for someone else. Like a cancer or heart patient.
brutusborn 5y ago
This doesn't mean the WHO "agrees". A poster explained this above: " That is one "failing" but not the most important one. No intramuscular shot seems to provide protection against infection of upper respiratory aerosol spread viruses. They provide IgG antibodies in the body serum, and that seeps into the lower lungs to provide protection from serious disease. But intramuscular vaccination does not provide even medium term protection against infection of the upper respiratory mucosal tissues. And that's really unfortunate but not unexpected if you knew anything about how influenza vaccination works. Those muscosal surface tissues require local IgA antibodies and resident B and T cells to prevent infections. Intramuscular vaccination does not cause this (though it does train the T cells that will go there when you do get infected). So, intramuscular vaccination is not preventing sars-cov-2 infection of the upper respiratory and spread of the virus to others. This does not mean intramuscular vaccination is not needed. It is the vital first step. The next step is an intranasal vaccination booster to provide resident T cells to the upper respiratory (as well as a brief period of IgA antibodies and B cell residence). If we're gonna get through this both "sides" have to acknowledge their failings. Intramuscular vaccination is both not enough and a required first step. Intranasal is next. Then we can finally start ending this pandemic. "

by Capira 5y ago

eqvinox 5y ago

The WHO agrees on "transmission or viral shedding". The WHO disagrees if anyone's tries to claim the vaccine doesn't help. The Pfizer BioNTech vaccine against COVID-19 has an efficacy of 95% against symptomatic SARS-CoV-2 infection. And each and every ICU bed taken up by an unvaccinated SARS-CoV-2 case taking a severe turn is an ICU bed that, with above 95% probability (yes, naïvely), could've been available for someone else. Like a cancer or heart patient.

brutusborn 5y ago

This doesn't mean the WHO "agrees". A poster explained this above: " That is one "failing" but not the most important one. No intramuscular shot seems to provide protection against infection of upper respiratory aerosol spread viruses. They provide IgG antibodies in the body serum, and that seeps into the lower lungs to provide protection from serious disease. But intramuscular vaccination does not provide even medium term protection against infection of the upper respiratory mucosal tissues. And that's really unfortunate but not unexpected if you knew anything about how influenza vaccination works. Those muscosal surface tissues require local IgA antibodies and resident B and T cells to prevent infections. Intramuscular vaccination does not cause this (though it does train the T cells that will go there when you do get infected). So, intramuscular vaccination is not preventing sars-cov-2 infection of the upper respiratory and spread of the virus to others. This does not mean intramuscular vaccination is not needed. It is the vital first step. The next step is an intranasal vaccination booster to provide resident T cells to the upper respiratory (as well as a brief period of IgA antibodies and B cell residence). If we're gonna get through this both "sides" have to acknowledge their failings. Intramuscular vaccination is both not enough and a required first step. Intranasal is next. Then we can finally start ending this pandemic. "