I would argue that most of the items on this list can be subdivided into two types of hype. short term hype (real advances that will happen in 1-2 years, but w

I would argue that most of the items on this list can be subdivided into two types of hype. short term hype (real advances that will happen in 1-2 years, but won't matter by 2030, because they are just a generational iteration) Over-hyped far-future research. (things where the possibilities have yet to be brought down to earth by the practical limits of implementing them broadly / cost effectively) When these things do happen, they tend to be a bit of a let-down, because they don't actually provide the promised revolutionary changes. These things basically have to be over-hyped in order to get the necessary funding to bring them to reality. Of the examples you have, I am only really excited about CRISPR, and to a lesser extent commercial spaceflight, and new nuclear. These have promise IMO, but I also don't expect them to be decade defining. Personally I don't think we know what the next breakthrough will be yet. I expect it to take us very much by surprise, and start out as something unthreatening which then grows to a disruptive size / scale.