As per my knowledge these technologies are currently being used and are in demand according to type of application: A)Large Enterprise Applications - .Net/Java

As per my knowledge these technologies are currently being used and are in demand according to type of application: A)Large Enterprise Applications - .Net/Java(J2EE) B)Web application 1)Server Side - Python+Django/Ruby+Rails/PHP+CodeIgnitor/node.js 2)Client Side - HTML5/CSS3/JavaScript/Ajax Libraries like jQuery, Yui, Closure/backbone.js 3)Database : MySQL and any noSQL database like mongodb C)Mobile Application 1)For iPhone - Objective-C 2)For Android - Android SDK/Java D)Web APIs - Facebook,Twitter,Google,Google+(when available) and Amazon Web Services E)Desktop Application - Large companies like google, yahoo, etc still stick to C++/Visual C++ but in general C# is also a decent choice. Keep checking sites like HN, Stack Overflow, Quora, Reddit etc and be genuinely interested about whats happening in technology and startup space. Who are the emerging startups and which technologies they are using..etc stuff. Try to learn one technology per month in weekends. I would also suggest you to read two books from 37signals - Getting Real and ReWork.