Interesting stuff. Most (basically all??) of our existing psychiatric drugs are small molecules. I presume this is related to how much of a pain getting protein

Interesting stuff. Most (basically all??) of our existing psychiatric drugs are small molecules. I presume this is related to how much of a pain getting proteins into the brain is - which is exactly what this research helps enable. They show that by grafting on specific structures into a protein (GLP-2) they can drastically increase its speed and effectiveness at delivering into the brain. I don't put much hope into GLP-2 being anywhere close to useful for actually treating anything in humans - I think it's just a nice model to demonstrate the technique. It's interesting, and I think the article does a great disservice because: a) This technique doesn't seem extendible to our existing drugs, which means this technique can't help mitigate some of the challenges of our existing drugs (one of them off the top of my head is that it just takes a long time for them to fully saturate your system, meaning its a total pain to figure out dosing). I feel like this should have been commented on. b) This technique potentially opens up an entire category of candidates that were previously ruled out. I feel like this should also been commented on directly.