2 ms·
I heard in a lecture that populations of human neurons are able to phase-lock or resonate to an oscillating stimulus that exceeds 1000s of Hz while mouse neuron
by dr_dshiv 5y ago
I heard in a lecture that populations of human neurons are able to phase-lock or resonate to an oscillating stimulus that exceeds 1000s of Hz while mouse neurons top out around 200 Hz. I haven’t been able to find citations for this. Hypothetically, the increase in temporal sensitivity might be related to the lower density of ion channels. Would a lower density of ion channels increase the capacitance of neurons?
- netizen-936824 5y agoI would think capacitance increases only if the number of leak channels change.
- disco_nap 5y agoThe majority of a neuron's transmembrane capacitance is attributed to the lipid membrane itself, so a lower density of ion channels should not appreciably alter capacitance. Action potential rates and the ability to phase-lock to inputs are significantly affected by the membrane time constant. Generally, membranes with lower conductances at rest and during spiking will have higher (slower) membrane time constants. This isn't a straightforward explanation for the ability of human some neurons to phase lock to higher frequencies. Impedance data across species relevant to this idea is in Extended Data Figure 2 and 5 of the paper.