The only FDA approved radiosensitizers are chemotherapy based (i.e. platinum, taxol). Vitamin B3 (Niacin) is a weak radiosensitizer at large doses. Finally hype

The only FDA approved radiosensitizers are chemotherapy based (i.e. platinum, taxol). Vitamin B3 (Niacin) is a weak radiosensitizer at large doses. Finally hyperthermia and increase atmospheric O2 also increase radiosensitivity. The common pathway they are theorized to work though is increasing reactive oxygen species. More reactive oxygen species, the more DNA damage, which leads to cell kill.