I also use a small keyboard (Keychron K3) even on my desktop, but once in the past when I switched to a full-sized keyboard, I intentionally switched to left-ha

I also use a small keyboard (Keychron K3) even on my desktop, but once in the past when I switched to a full-sized keyboard, I intentionally switched to left-hand mousing since the extra distance is only on the right side (with the numpad). I was also hoping the switch would help balance out my shoulders after years of right-hand mousing. It took a few days to get used to, but now I'm basically mouse/trackpad ambidextrous. I'm not sure if it helped my shoulder; I think maybe it did, but too many confounding factors.