3 ms·
If we were just interested in bioprospecting for new antibiotics, sure, there's more phage genome out there than human. But there's a unique value in understand
by jryb 5y ago
If we were just interested in bioprospecting for new antibiotics, sure, there's more phage genome out there than human. But there's a unique value in understanding how human antibiotic peptides work (or fail to work). Does expression of human antibiotic peptides decrease with age? Are they only expressed in certain tissues? There are important implications that we'll never uncover through non-human sequence mining. Additionally, human-derived peptides will probably have fewer side effects if used therapeutically, you never know what kind of immune response some random phage peptide will elicit.