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But is it solely the chemical changes in the brain that "fix" the depression, or does it also have to do with integrating what you've seen and experienced into

But is it solely the chemical changes in the brain that "fix" the depression, or does it also have to do with integrating what you've seen and experienced into your worldview?

abrichr 5y ago
Apologies in advance for the formatting, copied and pasted from YouTube transcript: https://youtu.be/Xu1FMCxoEFc?t=5928 https://youtu.be/Xu1FMCxoEFc?t=5928 99:33 But one of the things that came up 99:35 and is a fundamental question that I had, 99:37 that I think probably many of you are asking, 99:38 is does the experience that one has on these compounds 99:43 make a difference for whether or not somebody gains relief 99:46 from depression, from these psilocybin journeys or not? 99:50 In other words, does it matter what they talk about? 99:52 Does it matter what they think about? 99:53 Does it matter if they have a good trip or a bad trip? 99:56 And I don't want to hold you in too much suspense, 99:58 I'll let Matthew provide the more thorough answer. 100:00 But what's really interesting 100:02 is there are some common themes to psilocybin administration 100:08 and experience that lead to relief from depressive symptoms, 100:11 but they are subjectively very varied, 100:17 meaning that whether or not people feel 100:20 they had a good experience or a bad experience, 100:22 whether or not people thought about their parents 100:24 or thought about the color of the ceiling, 100:27 doesn't seem to have too much of an impact 100:30 on whether or not they receive relief 100:32 during these studies in these clinical studies. 100:37 It seems like different people can have 100:38 lots of different experiences and still receive benefit. 100:42 And that points to something deeper. 100:45 It points to the fact that these drugs, 100:48 which is really what they are, 100:49 are rewiring neural circuitry in a common way 100:53 despite a diversity of experience while on the drug. 100:57 And that itself is really interesting. 100:58 And it takes us back to a place that we've been before 101:01 in this discussion, which is layer five of the cortex. 101:04 This area that ketamine seems to impact as well 101:06 by generating rhythms of the, 101:08 I mentioned one to three Hertz activity 101:10 in layer five of certain areas of the cortex.

But is it solely the chemical changes in the brain that "fix" the depression, or does it also have to do with integrating what you've seen and experienced into your worldview?

abrichr 5y ago

Apologies in advance for the formatting, copied and pasted from YouTube transcript: https://youtu.be/Xu1FMCxoEFc?t=5928 https://youtu.be/Xu1FMCxoEFc?t=5928 99:33 But one of the things that came up 99:35 and is a fundamental question that I had, 99:37 that I think probably many of you are asking, 99:38 is does the experience that one has on these compounds 99:43 make a difference for whether or not somebody gains relief 99:46 from depression, from these psilocybin journeys or not? 99:50 In other words, does it matter what they talk about? 99:52 Does it matter what they think about? 99:53 Does it matter if they have a good trip or a bad trip? 99:56 And I don't want to hold you in too much suspense, 99:58 I'll let Matthew provide the more thorough answer. 100:00 But what's really interesting 100:02 is there are some common themes to psilocybin administration 100:08 and experience that lead to relief from depressive symptoms, 100:11 but they are subjectively very varied, 100:17 meaning that whether or not people feel 100:20 they had a good experience or a bad experience, 100:22 whether or not people thought about their parents 100:24 or thought about the color of the ceiling, 100:27 doesn't seem to have too much of an impact 100:30 on whether or not they receive relief 100:32 during these studies in these clinical studies. 100:37 It seems like different people can have 100:38 lots of different experiences and still receive benefit. 100:42 And that points to something deeper. 100:45 It points to the fact that these drugs, 100:48 which is really what they are, 100:49 are rewiring neural circuitry in a common way 100:53 despite a diversity of experience while on the drug. 100:57 And that itself is really interesting. 100:58 And it takes us back to a place that we've been before 101:01 in this discussion, which is layer five of the cortex. 101:04 This area that ketamine seems to impact as well 101:06 by generating rhythms of the, 101:08 I mentioned one to three Hertz activity 101:10 in layer five of certain areas of the cortex.