It's probably not "a few weeks and then never again" -- I'm not depressed, but anecdotes from people I know who've tried mushrooms at home for this suggest that

It's probably not "a few weeks and then never again" -- I'm not depressed, but anecdotes from people I know who've tried mushrooms at home for this suggest that one trip produces a noticeable improvement that fades over time. It's possible that the full experience with a trained therapist who supervises the trip could produce longer-lasting changes, of course.