It's genetic, and partial. Unless you know your genetics, telling someone what they need is useless. I know my genetics. And I tried Thiamine years ago. It mad

It's genetic, and partial. Unless you know your genetics, telling someone what they need is useless. I know my genetics. And I tried Thiamine years ago. It made me manic, most likely because my real issue was a depletion of manganese that not only increase superoxide damage in my mitochondria, but also inhibited my TCA cycle in the wrong location. Taking thiamine pushed my TCA cycle but since my TCA cycle was inhibited, the metabolites that were created caused other issues. Or it could have been that the Thiamine meant a build up of NADH that my Complex I could not handle and it just created more (e-) in my mitochondrial matrix and then more superoxdides.