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As someone with a Complex I Deficiency I did not know you could "unblock" the electron transport chain. Taking these supplements without knowing your genetics w

by podgaj 5y ago

As someone with a Complex I Deficiency I did not know you could "unblock" the electron transport chain. Taking these supplements without knowing your genetics will result in undue suffering and confusion. And to speak of the election transport chain and not include Manganese and ascorbic acid means this comment should not be taken at face value. https://www.jci.org/articles/view/118798 https://www.jci.org/articles/view/118798 In fact, it is the oxidative stress that damages the ETC. https://pubmed.ncbi.nlm.nih.gov/21699493/ https://pubmed.ncbi.nlm.nih.gov/21699493/ As far as ME/CFS and its' similarities with Long Covid, the answer is here is fixing an ROS imbalance as well, IMHO: https://www.sciencedirect.com/science/article/pii/S2095882X20300839 https://www.sciencedirect.com/science/article/pii/S2095882X2...

garganzol 5y ago
> Complex I Deficiency Acquired or genetical? > Manganese and ascorbic acid Ascorbic acid is usually a part of vitamin C supplementation. Multivitamin complexes do contain manganese, but one needs to check. Did not know they were essential. Thanks for the information. Besides that, there is a work of Dr Costantini that lays down the basis of ETC "restart" with full enzymatical saturation. Take a look [1]. Definitely works for some people, sometimes to a great surprise after decades of suffering. [1] https://www.youtube.com/watch?v=O-aQHxp97oA https://www.youtube.com/watch?v=O-aQHxp97oA
- xattt 5y ago
  > Ascorbic acid is usually a part of vitamin C supplementation. Ascorbic acid is Vitamin C.
- podgaj 5y ago
  It's genetic, and partial. Unless you know your genetics, telling someone what they need is useless. I know my genetics. And I tried Thiamine years ago. It made me manic, most likely because my real issue was a depletion of manganese that not only increase superoxide damage in my mitochondria, but also inhibited my TCA cycle in the wrong location. Taking thiamine pushed my TCA cycle but since my TCA cycle was inhibited, the metabolites that were created caused other issues. Or it could have been that the Thiamine meant a build up of NADH that my Complex I could not handle and it just created more (e-) in my mitochondrial matrix and then more superoxdides.

by podgaj 5y ago

garganzol 5y ago

> Complex I Deficiency Acquired or genetical? > Manganese and ascorbic acid Ascorbic acid is usually a part of vitamin C supplementation. Multivitamin complexes do contain manganese, but one needs to check. Did not know they were essential. Thanks for the information. Besides that, there is a work of Dr Costantini that lays down the basis of ETC "restart" with full enzymatical saturation. Take a look [1]. Definitely works for some people, sometimes to a great surprise after decades of suffering. [1] https://www.youtube.com/watch?v=O-aQHxp97oA https://www.youtube.com/watch?v=O-aQHxp97oA

xattt 5y ago
> Ascorbic acid is usually a part of vitamin C supplementation. Ascorbic acid is Vitamin C.
podgaj 5y ago
It's genetic, and partial. Unless you know your genetics, telling someone what they need is useless. I know my genetics. And I tried Thiamine years ago. It made me manic, most likely because my real issue was a depletion of manganese that not only increase superoxide damage in my mitochondria, but also inhibited my TCA cycle in the wrong location. Taking thiamine pushed my TCA cycle but since my TCA cycle was inhibited, the metabolites that were created caused other issues. Or it could have been that the Thiamine meant a build up of NADH that my Complex I could not handle and it just created more (e-) in my mitochondrial matrix and then more superoxdides.