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Maybe. However tryptophan by itself won't heal you once the pathology onset has occurred. The usual scheme is to use a combination of medications in order to u

Maybe. However tryptophan by itself won't heal you once the pathology onset has occurred. The usual scheme is to use a combination of medications in order to unblock the electron transport chain while inhibiting the inflammatory response. If you want to know more, read the comments section of the video above. Some of them contain hints and even actionable recipes. Keywords, hints, typical doses: B1/Thiamin (in form of HCL 100-2000 mg, Benfothiamin 100-600 mg, TTFD 50-800 mg), B3/Niacin (in form of nicotinic acid - never, nicotinamide 250 mg, Nicotinamide Riboside 100-400 mg), Mg (200-400 mg), K (50-300 mg), B2 (50-400 mg), C (150-500 mg), D (5000 I.U. - 400 000 I.U), Aspirin (150-500 mg), CoQ10 (60-200 mg), Alpha-lipoic Acid (60-300 mg), Acetyl-L-Carnitine (500 mg), Zinc (20-50 mg), Copper (2mg), N-Acetyl-Cysteine/NAC (600-1800 mg), Betaine (50 mg), Quercetin (250 mg), Trans-reservatrol (150 mg), Multivitamin Complex (obligatory when large doses of B vitamins are taken). Please note that provided list of medications is for reference only. Those medications are carefully combined to reach the desired therapeutic effect. B1, B3, Multivitamin Complex, C, D and Mg are essential elements. Others are used in more involved cases. Nutritional correction is obligatory: totally no alcohol, minimize high carbs (< 50 g of sugar per day), totally avoid sweeteners (with the exception of stevia), avoid highly-processed food. Milk and meat are god send for people in that condition. Avoid the prolonged periods of hunger but be careful to not eat too much. Having a slightest sense of hunger after the meal is beneficial. Make at least 2 hour intervals between meals.

podgaj 5y ago
As someone with a Complex I Deficiency I did not know you could "unblock" the electron transport chain. Taking these supplements without knowing your genetics will result in undue suffering and confusion. And to speak of the election transport chain and not include Manganese and ascorbic acid means this comment should not be taken at face value. https://www.jci.org/articles/view/118798 https://www.jci.org/articles/view/118798 In fact, it is the oxidative stress that damages the ETC. https://pubmed.ncbi.nlm.nih.gov/21699493/ https://pubmed.ncbi.nlm.nih.gov/21699493/ As far as ME/CFS and its' similarities with Long Covid, the answer is here is fixing an ROS imbalance as well, IMHO: https://www.sciencedirect.com/science/article/pii/S2095882X20300839 https://www.sciencedirect.com/science/article/pii/S2095882X2...
- garganzol 5y ago
  > Complex I Deficiency Acquired or genetical? > Manganese and ascorbic acid Ascorbic acid is usually a part of vitamin C supplementation. Multivitamin complexes do contain manganese, but one needs to check. Did not know they were essential. Thanks for the information. Besides that, there is a work of Dr Costantini that lays down the basis of ETC "restart" with full enzymatical saturation. Take a look [1]. Definitely works for some people, sometimes to a great surprise after decades of suffering. [1] https://www.youtube.com/watch?v=O-aQHxp97oA https://www.youtube.com/watch?v=O-aQHxp97oA
  - xattt 5y ago
    > Ascorbic acid is usually a part of vitamin C supplementation. Ascorbic acid is Vitamin C.
  - podgaj 5y ago
    It's genetic, and partial. Unless you know your genetics, telling someone what they need is useless. I know my genetics. And I tried Thiamine years ago. It made me manic, most likely because my real issue was a depletion of manganese that not only increase superoxide damage in my mitochondria, but also inhibited my TCA cycle in the wrong location. Taking thiamine pushed my TCA cycle but since my TCA cycle was inhibited, the metabolites that were created caused other issues. Or it could have been that the Thiamine meant a build up of NADH that my Complex I could not handle and it just created more (e-) in my mitochondrial matrix and then more superoxdides.
DarknessFalls 5y ago
Why is a multivitamin complex necessary after large doses of B vitamins? I thought that B vitamins are just water-soluble and your body removes the excess.
- garganzol 5y ago
  Vitamins are catalysts of chemical reactions. When you speed up reactions dependent on, say, B1 - you should also be sure that adjacent reactions are fastened up. Otherwise, this may cause an imbalance which can be disastrous or even fatal. The same rule goes to minerals - when you take vitamins, the reaction speeds increase and they start to consume significantly more substrates causing electrolyte disbalances, which can be disastrous and even fatal. That's why you have to make sure that you take enough of Mg, K, P when you get vitamins as well.
  - podgaj 5y ago
    As an example I will show how taking his dose riboflavin might increase the need for Zinc and Magnesium. To turn Riboflavin into FMN using an enzyme called RFK, which needs zinc and magnesium as cofactors: https://www.uniprot.org/uniprot/Q969G6 https://www.uniprot.org/uniprot/Q969G6 The it turns FMN to turn into FAD using FLAD1, which needs Magnesium as a cofactor. https://www.uniprot.org/uniprot/Q8NFF5 https://www.uniprot.org/uniprot/Q8NFF5

podgaj 5y ago

As someone with a Complex I Deficiency I did not know you could "unblock" the electron transport chain. Taking these supplements without knowing your genetics will result in undue suffering and confusion. And to speak of the election transport chain and not include Manganese and ascorbic acid means this comment should not be taken at face value. https://www.jci.org/articles/view/118798 https://www.jci.org/articles/view/118798 In fact, it is the oxidative stress that damages the ETC. https://pubmed.ncbi.nlm.nih.gov/21699493/ https://pubmed.ncbi.nlm.nih.gov/21699493/ As far as ME/CFS and its' similarities with Long Covid, the answer is here is fixing an ROS imbalance as well, IMHO: https://www.sciencedirect.com/science/article/pii/S2095882X20300839 https://www.sciencedirect.com/science/article/pii/S2095882X2...

garganzol 5y ago
> Complex I Deficiency Acquired or genetical? > Manganese and ascorbic acid Ascorbic acid is usually a part of vitamin C supplementation. Multivitamin complexes do contain manganese, but one needs to check. Did not know they were essential. Thanks for the information. Besides that, there is a work of Dr Costantini that lays down the basis of ETC "restart" with full enzymatical saturation. Take a look [1]. Definitely works for some people, sometimes to a great surprise after decades of suffering. [1] https://www.youtube.com/watch?v=O-aQHxp97oA https://www.youtube.com/watch?v=O-aQHxp97oA
- xattt 5y ago
  > Ascorbic acid is usually a part of vitamin C supplementation. Ascorbic acid is Vitamin C.
- podgaj 5y ago
  It's genetic, and partial. Unless you know your genetics, telling someone what they need is useless. I know my genetics. And I tried Thiamine years ago. It made me manic, most likely because my real issue was a depletion of manganese that not only increase superoxide damage in my mitochondria, but also inhibited my TCA cycle in the wrong location. Taking thiamine pushed my TCA cycle but since my TCA cycle was inhibited, the metabolites that were created caused other issues. Or it could have been that the Thiamine meant a build up of NADH that my Complex I could not handle and it just created more (e-) in my mitochondrial matrix and then more superoxdides.

DarknessFalls 5y ago

Why is a multivitamin complex necessary after large doses of B vitamins? I thought that B vitamins are just water-soluble and your body removes the excess.

garganzol 5y ago
Vitamins are catalysts of chemical reactions. When you speed up reactions dependent on, say, B1 - you should also be sure that adjacent reactions are fastened up. Otherwise, this may cause an imbalance which can be disastrous or even fatal. The same rule goes to minerals - when you take vitamins, the reaction speeds increase and they start to consume significantly more substrates causing electrolyte disbalances, which can be disastrous and even fatal. That's why you have to make sure that you take enough of Mg, K, P when you get vitamins as well.
- podgaj 5y ago
  As an example I will show how taking his dose riboflavin might increase the need for Zinc and Magnesium. To turn Riboflavin into FMN using an enzyme called RFK, which needs zinc and magnesium as cofactors: https://www.uniprot.org/uniprot/Q969G6 https://www.uniprot.org/uniprot/Q969G6 The it turns FMN to turn into FAD using FLAD1, which needs Magnesium as a cofactor. https://www.uniprot.org/uniprot/Q8NFF5 https://www.uniprot.org/uniprot/Q8NFF5