As a public health analysis, there is still a tradeoff between exposure of the population directly to the full spike protein vs in a more constrained vaccine. E

As a public health analysis, there is still a tradeoff between exposure of the population directly to the full spike protein vs in a more constrained vaccine. Especially if, as most governments and economic policies have decided that they are more or less going to forego the bulk of systematic non-medical social measures to protect public health. And as the paper itself suggests - an even more focused approach to vaccines could be used.