4 ms·

Are there other promising anxiolytics on the horizon? Even more basic, what are the best options available now?

gehwartzen 5y ago
Phenibut fits the bill and is more widely used and prescribed in Russia. In the US you can buy it in chemical form as its unregulated. Its a quite potent anxiolytic working as a GABA-B Antagonist. I recommend doing a lot of research though as there are quite a few people that seem to either get hooked on or have a terrible time coming off of this drug/chemical. I personally never had those problems but something to be aware of.
- Ginden 5y ago
  Most of GABA agonists can be addictive and seemingly all of them are dependence-forming.
Ginden 5y ago
> Are there other promising anxiolytics on the horizon? Even more basic, what are the best options available now? Well, anxiolytics in general can be grouped in two groups - for acute treatment and for long-term treatment. For acute treatment, benzodiazepines remain good choice. Therapy with benzodiazepines should not last for more than 6 weeks. Another option is use of 1st generation antihistamines, but tolerance usually develops. For long term treatment, there are quite many options. Most of antidepressants exhibit anxiolytic effects and they are relatively safe for long-term use. Sympatholytics are also useful - seemingly, slowing heart rate reduces anxiety in mammals. Pregabalin is widely used for anxiety, because it's relatively safe for long-term use. The gold standard is therapy (first line for anxiety should be CBT). Medication is often warranted but should be used in conjunction with therapy. Overall, most of mental disorders are complex mixture of psychological and biological factors and best possible treatment usually combines therapy and medication. There is hypothetical logical link - most of antidepressants increase neuroplasticity and neuroplasticity is thought to be necessary for therapy to work.

Phenibut fits the bill and is more widely used and prescribed in Russia. In the US you can buy it in chemical form as its unregulated. Its a quite potent anxiolytic working as a GABA-B Antagonist. I recommend doing a lot of research though as there are quite a few people that seem to either get hooked on or have a terrible time coming off of this drug/chemical. I personally never had those problems but something to be aware of.

Ginden 5y ago
Most of GABA agonists can be addictive and seemingly all of them are dependence-forming.

Ginden 5y ago

> Are there other promising anxiolytics on the horizon? Even more basic, what are the best options available now? Well, anxiolytics in general can be grouped in two groups - for acute treatment and for long-term treatment. For acute treatment, benzodiazepines remain good choice. Therapy with benzodiazepines should not last for more than 6 weeks. Another option is use of 1st generation antihistamines, but tolerance usually develops. For long term treatment, there are quite many options. Most of antidepressants exhibit anxiolytic effects and they are relatively safe for long-term use. Sympatholytics are also useful - seemingly, slowing heart rate reduces anxiety in mammals. Pregabalin is widely used for anxiety, because it's relatively safe for long-term use. The gold standard is therapy (first line for anxiety should be CBT). Medication is often warranted but should be used in conjunction with therapy. Overall, most of mental disorders are complex mixture of psychological and biological factors and best possible treatment usually combines therapy and medication. There is hypothetical logical link - most of antidepressants increase neuroplasticity and neuroplasticity is thought to be necessary for therapy to work.