A funny thing: some drugs which work in vitro don't work in actual cells because actual cells are much more crowded than liquid in a beaker. This also makes it

A funny thing: some drugs which work in vitro don't work in actual cells because actual cells are much more crowded than liquid in a beaker. This also makes it harder to simulate on computer, since you have a ton more interactions to evaluate. Also, many proteins require this crowd pressure to keep them in the proper functional shape. https://en.wikipedia.org/wiki/Macromolecular_crowding https://en.wikipedia.org/wiki/Macromolecular_crowding