3 ms·

I'm pleased the war on drugs and social stigma gradually stops blocking research on psychedelics but I wish they would also study lesser-known substances and co

I'm pleased the war on drugs and social stigma gradually stops blocking research on psychedelics but I wish they would also study lesser-known substances and compare. E.g. psilocybin (4-PO-DMT) has an interesting synthetic alternative psilacetin (4-AcO-DMT) - I would love to see it as an extra thing they would compare to in such studies.

lstodd 5y ago
5-MeO is also interesting. https://www.ghres.com/pipeline https://www.ghres.com/pipeline
- qwerty456127 5y ago
  It's extremely interesting but it makes less sense to compare it to psilocybin (way too different in experience, dosage and the way you take it) and there in fact is some scientific research activity on it going on. It has already made it to some scientific papers, Forbes and HN.
- gehwartzen 5y ago
  Yeah, this one from my own personal experience almost seems like a better candidate. You experience a lot of mental openness/oneness/expansion but there is really no visual component to it. Its helped me quite a bit at times. For those that don't know it's the chemical present in the glands of the Sonoran desert toad.
  - deleted 5y ago
    [deleted]
Alex3917 5y ago
The issue is that they’d then have to pay for preclinical studies to determine safety, which would add millions of dollars to the budget. Whereas for psilocybin that work was largely done decades ago.
- qwerty456127 5y ago
  Nice point. By the way, IMO, some long-known and safe substances should also be given new tries in combination with the researched psychedelics. E.g. I believe piracetam is a great thing to take half an hour before you take MDMA - it may catalyse the effect (in a therapeutic setting especially as speaking boost is among its effects) and prevent hangover. It's not approved by the FDA but widely used in Europe and obviously (given a really huge base of empiric evidence) safe.
elevenoh 5y ago
Distributed anecdotes derisk the lesser known substances before the $ & reputation flow in to study it w/ a hypothesis. I'm sure it'll happen sooner than later.
0xdeadb00f 5y ago
4-aco-DMT has been sold on DNMs and used by recreational drug users for a while now as an alternative to psylocibin

lstodd 5y ago

5-MeO is also interesting. https://www.ghres.com/pipeline https://www.ghres.com/pipeline

qwerty456127 5y ago
It's extremely interesting but it makes less sense to compare it to psilocybin (way too different in experience, dosage and the way you take it) and there in fact is some scientific research activity on it going on. It has already made it to some scientific papers, Forbes and HN.
gehwartzen 5y ago
Yeah, this one from my own personal experience almost seems like a better candidate. You experience a lot of mental openness/oneness/expansion but there is really no visual component to it. Its helped me quite a bit at times. For those that don't know it's the chemical present in the glands of the Sonoran desert toad.
- deleted 5y ago
  [deleted]

Alex3917 5y ago

The issue is that they’d then have to pay for preclinical studies to determine safety, which would add millions of dollars to the budget. Whereas for psilocybin that work was largely done decades ago.

qwerty456127 5y ago
Nice point. By the way, IMO, some long-known and safe substances should also be given new tries in combination with the researched psychedelics. E.g. I believe piracetam is a great thing to take half an hour before you take MDMA - it may catalyse the effect (in a therapeutic setting especially as speaking boost is among its effects) and prevent hangover. It's not approved by the FDA but widely used in Europe and obviously (given a really huge base of empiric evidence) safe.

elevenoh 5y ago

Distributed anecdotes derisk the lesser known substances before the $ & reputation flow in to study it w/ a hypothesis. I'm sure it'll happen sooner than later.

0xdeadb00f 5y ago

4-aco-DMT has been sold on DNMs and used by recreational drug users for a while now as an alternative to psylocibin