4 ms·

Ivermectin isn't a protease inhibitor though?

• twofornone 5y ago
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/ Almost as if after clinical evidence (sure, arguably week) and a promising mechanism of action (yeah, in silico) a widespread, double blind RCT should have been conducted a year ago...
  • lightavalanche 5y ago
    Another link: https://www.nature.com/articles/s42003-020-01577-x https://www.nature.com/articles/s42003-020-01577-x Paxlovid and Ivermectin are both 3CLPro protease inhibitors.
  • reureu 5y ago
    My question/comment was not intended to spark discussion about the efficacy of ivermectin for covid-19, just confused at the classification of ivermectin as a protease inhibitor. I don't think most doctors, pharmacists, or epidemiologists would think of ivermectin as a protease inhibitor, even with a few in silica studies suggesting protease activity in certain circumstances. There have been at least 14 RCTs, including double blinded studies. In meta-analysis, "ivermectin was not efficacious at managing COVID-19"[1]. I won't engage further in that discussion. [1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500108/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500108/