I use http://cherrypy.org/ http://cherrypy.org/ (behind a nginx revproxy) to my satisfaction. The data is stored either in http://www.mongodb-is-web-scale.com/

I use http://cherrypy.org/ http://cherrypy.org/ (behind a nginx revproxy) to my satisfaction. The data is stored either in http://www.mongodb-is-web-scale.com/ http://www.mongodb-is-web-scale.com/ , or in MySQL. Disclaimer: these websites are not designed for 50.000 hits per second, but during benchmarking I get consistent times like 4 msec per page, and I'm confident that nginx can handle many slow clients simultaneously.