Reduction in Complement 3C seems to be correlated with protection from Alzheimer's in mice[0]. Good news for Lupus patients (who typically have low 3C3). "Bloc

Reduction in Complement 3C seems to be correlated with protection from Alzheimer's in mice[0]. Good news for Lupus patients (who typically have low 3C3). "Blocking complement function by deleting C3 rescues plaque-associated synapse loss in PS2APP mice and ameliorates neuron loss and brain atrophy in TauP301S mice, improving neurophysiological and behavioral measurements. In addition, C3 protein is elevated in AD patient brains, including at synapses, and levels and processing of C3 are increased in AD patient CSF and correlate with tau." An earlier cohort study[1] of nearly 100k humans said "Low baseline levels of complement C3 were associated with high risk of AD" 1: https://pubmed.ncbi.nlm.nih.gov/30243924/ https://pubmed.ncbi.nlm.nih.gov/30243924/ 2: https://www.cell.com/cell-reports/pdf/S2211-1247(19)30964-7.pdf https://www.cell.com/cell-reports/pdf/S2211-1247(19)30964-7.... The immune system is a crazy thing about which the medical community knows far less than one would think. There's some fascinating potential in there if it can be well-understood (not just 'hacked').