4 ms·
Autoimmune issues may fit that bill in people with the right genetics. They can cause and/or contribute to CKD, which could push someone into kidney failure wit
by omgwtfbyobbq 5y ago
Autoimmune issues may fit that bill in people with the right genetics. They can cause and/or contribute to CKD, which could push someone into kidney failure with other insults (eg dehydration), and can also contribute to dementia.
- JamesBarney 5y agoThat would give us the opposite result, higher rates of dementia among organ transplants. It would have to be something that causes kidney failure, but prevents dementia.
- omgwtfbyobbq 5y agoHow so? The autoimmunity would contribute to kidney failure when unchecked, and after failure and transplant, immunosuppressive meds would reduce the chances of developing dementia related to autoimmunity.
- JamesBarney 5y agoBut according to this study, organ transplant patients have a much lower risk of dementia compared to the general population, not just people who have autoimmune diseases.
- omgwtfbyobbq 5y agoIt could be that autoimmune activity/genetics, even if it doesn't result in a specific disease, contributes to certain aspects of dementia. Take Celiac disease as an example. It only affects ~1% of the population, but ~30% of the population has the two genes (HLA-DQ2 and DQ8) that are most strongly associated with it and those genes are also associated with other autoimmune diseases. There are similar thoughts with respect to the hygiene hypothesis and autoimmune/immune-related disease. https://en.wikipedia.org/wiki/Hygiene_hypothesis#Overview https://en.wikipedia.org/wiki/Hygiene_hypothesis#Overview Other diseases, like Parkinson's, are also associated with autoimmune diseases. I suspect that there's some trade-off with respect to the effectiveness of the immune system/how well it deals with infections/cancer and the incidence of certain diseases/pathologies, but it's not something that's as straightforward as we would like it to be.