TLDR: some vaccine maybe safer than other. This article calls out "full–length spike–based vaccine". "suggests that the use of antigenic epitopes of the spike

TLDR: some vaccine maybe safer than other. This article calls out "full–length spike–based vaccine". "suggests that the use of antigenic epitopes of the spike as a SARS–CoV–2 vaccine might be safer and more efficacious than the full–length spike" "This work will improve the understanding of COVID–19 pathogenesis and provide new strategies for designing more efficient and safer vaccines."