> Homebrew also messes with /usr/local (it stores symlinks there), so this could interfere with the native package manager, I suppose. For example, if you insta

> Homebrew also messes with /usr/local (it stores symlinks there), so this could interfere with the native package manager, I suppose. For example, if you install and then purge a package, it could overwrite symlinks and then remove them (also if the package is a dependency of the package you're interested in). This is the output of "tree /usr/local" on my non-experimental system: marco@marco-Inspiron-3421:~$ tree /usr/local/ /usr/local/ ├── bin ├── etc ├── games ├── include ├── lib │ ├── python2.7 │ │ ├── dist-packages │ │ └── site-packages │ └── python3.8 │ └── dist-packages ├── man -> share/man ├── sbin ├── share │ ├── ca-certificates │ ├── fonts │ ├── man │ ├── sgml │ │ ├── declaration │ │ ├── dtd │ │ ├── entities │ │ ├── misc │ │ └── stylesheet │ ├── texmf │ └── xml │ ├── declaration │ ├── entities │ ├── misc │ └── schema └── src 29 directories, 0 files It has a lot of packages installed but, as you can see, the package manager never wrote a file in /usr/local. So I think it is safe to assume things installed to /usr/local will not interfere with the package manager. > Also, how would you install Python wheels in a system-wide manner? No sure, but I think it can be done with guix.