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Heroin, interestingly enough. IIRC they screened pain medicine recipients for depressive symptoms and in this way determined opiates relieve major depression mo
by R0b0t1 5y ago
Heroin, interestingly enough. IIRC they screened pain medicine recipients for depressive symptoms and in this way determined opiates relieve major depression more efficaciously than SSRIs.
- jamal-kumar 5y agoconsider quitting while you're ahead.
- ironmagma 5y agoYes, and a close relative (oxycodone) is something I’ve had experience with and can confirm it’s quite good at curing the depression. The problem is the permanent brain damage and/or death it will cause when taken long-term. Link < https://www.drugabuse.gov/publications/research-reports/heroin/what-are-long-term-effects-heroin-use https://www.drugabuse.gov/publications/research-reports/hero...>
- R0b0t1 5y agoI don't see opiates as a tenable longterm solution but I mentioned heroin because it's only long term side effect as far as I know is constipation, which can be managed. Same with morphine. My point in bringing this up is why accept SSRIs if they have more side effects and are less efficacious than heroin?
- ironmagma 5y agoHeroin is highly addictive and has a high risk of overdose. There are alternatives to SSRIs, such as SNRIs and tricyclics.
- R0b0t1 5y agoBoth irrelevant with medical supervision. SSRIs are highly addictive too; many people never stop taking them.
- ironmagma 5y agoOverdose is not impossible just because there's a guy in a white suit telling you what to do. People will still take more than they should. > SSRIs aren't addictive [1] There are also a large number of side effects and risks associated with heroin; it's not just constipation as you say. [2] [1] https://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825#:~:text=SSRIs%20aren't%20addictive.,and%20safely%20decrease%20your%20dose https://www.mayoclinic.org/diseases-conditions/depression/in.... [2] https://www.drugabuse.gov/publications/drugfacts/heroin https://www.drugabuse.gov/publications/drugfacts/heroin
- R0b0t1 5y agoDid you read your 2nd link? All of the typically bad sides in the second grouping are related to poor hygiene and needle sharing. The first grouping is more benign than most antidepressant sides.
- ironmagma 5y agoYes, I did. Nowhere does it say that. If you want to get a point of reference for what heroin might look like if it wasn't a street drug, oxycodone is quite similar yet distributed without the additives found on the street since it is manufactured by big pharma. Still, it is associated with respiratory depression.
- R0b0t1 5y agoI know it doesn't say that but it should be obvious most of them are due to poor IV administration. You don't need to administer heroin or morphine via IV. True, people occasionally OD on prescription medication, but it's usually as a rebound after having the prescription withdrawn and then finding more drugs.
- ironmagma 5y agoThat can happen with prescription drugs too though. People lose access to their insurance and then end up going off the drug too fast. The bottom line is, don't you think if they could sell more of this drug, they would? Opiates are a pretty terrible choice for an antidepressant for multiple reasons.