>On the other hand, there are other classes of psychedelics that are unambiguously good: tryptamines (e.g., psilocybin) and phenethylamines (e.g., mescaline).

>On the other hand, there are other classes of psychedelics that are unambiguously good: tryptamines (e.g., psilocybin) and phenethylamines (e.g., mescaline). I don't know that I would necessarily classify hallucinogenic psychedelics as unambiguously good. I suspect the potential negative effects are understudied and under reported. Beyond hallucinogen persisting perception disorder (admittedly rare), medium-long term induced psychosis (also probably rare), while users frequently report positive effects both short and long term, there are potentially profound psychological/neurological alterations occurring post use which may not be obviously detrimental. What further complicates the issue is that, because of the strong dependence on existing psychological state (set and setting), its quite possible that a user's culture becomes a significant confounding factor and that some groups of people may in fact be worse off after using some or all such psychedelics. Personally, a year or two post experience I noticed that certain emotions are more apparent to my perception which honestly I would have preferred to continue ignoring. I still suspect that for the vast majority of people hallucinogens can be positive but let's not make the mistake of preemptively asserting that they are harmless.