3 ms·
MAOIs have potentially serious dietary interactions and side effects. They can cause serotonin sickness just by taking it with OTC tryptophan supplements. SSR
by bduerst 5y ago
MAOIs have potentially serious dietary interactions and side effects. They can cause serotonin sickness just by taking it with OTC tryptophan supplements.
SSRIs are not perfect but have a safer track record of being a first-attack against depression and anxiety, before having to resort to bigger guns like MAOIs.
- jamal-kumar 5y agoThis is actually the biggest thing keeping this line of treatment from being the preference, but when it comes to reversible vs irreversible MAOIs the dietary interactions are actually not a concern![1] It was actually my first comment when I was told about this, but as it turns out you're more looking at potential drug interactions with the reversible MAOIs. The dietary interactions definitely stand with the irreversible MAOIs in the first generation antidepressants, which I think are generally reserved these days for really serious depression cases that don't respond to other treatment, or parkinsons like symptoms, or people going on jungle treks to drink shaman brews. I think the benefit of treatment kicking in immediately is really key as well, 2 weeks is a long time to wait for a drug to work when you're potentially on the brink of suicide. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188542/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188542/