3 ms·
> When the DSMC met on Aug 5, 2021, it recommended that the TOGETHER trial stop randomly assigning patients to the fluvoxamine group, as this comparison had met
by darkerside 5y ago
> When the DSMC met on Aug 5, 2021, it recommended that the TOGETHER trial stop randomly assigning patients to the fluvoxamine group, as this comparison had met the prespecified superiority criterion for the primary endpoint (prespecified superiority threshold 97·6%).
That seems problematic. Did they stop the study because they had achieved statistical significance?
- scarmig 5y agoAnother issue is that they were testing multiple drugs, none of which had a statistically significant effect. Classic p hacking. https://xkcd.com/882/ https://xkcd.com/882/
- scotty79 5y agoAssesing 7 promising substances to determine which one if any does anything and getting 30% effect on one and no effect on the rest is p-hacking? Is science allowed to research only one substance for specific purpose at any time to sufficiently avoid p-hacking for you? Also if I read correctly they got >0.60 not >0.05