Short answer: nobody knows. In any case, I don't believe an answer is realistically even possible because we can't easily isolate all the other factors involved

Short answer: nobody knows. In any case, I don't believe an answer is realistically even possible because we can't easily isolate all the other factors involved. Also, you'll have to consider affinity maturation and the cutoff for B-cell specificity for an antigen to clearly define what you even mean by 'remembering a protein antigen'. https://en.wikipedia.org/wiki/Activation-induced_cytidine_deaminase https://en.wikipedia.org/wiki/Activation-induced_cytidine_de... https://en.wikipedia.org/wiki/Affinity_maturation https://en.wikipedia.org/wiki/Affinity_maturation ^ and many more that will probably just end up amounting to a couple of years of study!