yes to all. the early days of biochemistry were heavily dependent on x-ray crystallography, meaning the subject structure was in crystalline form, meaning ther

yes to all. the early days of biochemistry were heavily dependent on x-ray crystallography, meaning the subject structure was in crystalline form, meaning there was a bias toward understanding of structures that facilitated crystalization. sequencing and structural studies[folding] were slow tedious wetlab efforts until mid 90s when computing power was of caliber, and shared across the internet, we now have such computation cheaper smaller, and locally. like any jigsaw puzzle, the more pieces correctly placed the easier it becomes to progress.