3 ms·
That's true. But that's the nature of all influenzas: your immunity is only as good as the last generation of infectious agent. The reason they choose the spik
by LatteLazy 5y ago
That's true. But that's the nature of all influenzas: your immunity is only as good as the last generation of infectious agent.
The reason they choose the spike protein is because it's a vital component in its current state. So to change it and avoid immunity means covid can no longer infect human cells. The only way around this is to radically change the spike protein AND to miraculously find a new spike protein that works for humans.
That's why around 1bn people have been vaccinated, exposed to covid 19 and no new spike protein that circumvents the vaccines has evolved yet.
Such a change to the nucleocapsid is much easier to make as it doesn't need to interact with human cells.
- mathw 5y agoThere's at least one team working on a vaccine that targets another feature of SARS-CoV-2 that changes less than the spike protein does (the interview I heard called it "the N protein"), which could give us a better long-term way to deal with variants. Although I guess it shifts the selective pressure from spike protein mutations to N protein mutations instead. Can't win! Nature is wiggly.