3 ms·
You see the poly(A) sequence at the end? That is what stabalizes the entire structure so that it doesn't denature. I called it a "base", but you are right tha
by q1w2 5y ago
You see the poly(A) sequence at the end? That is what stabalizes the entire structure so that it doesn't denature. I called it a "base", but you are right that it's not adding to the size of the overall structure much.
The point is that the normal virus protein obviously doesn't have that - it's human design to create stability.
My point was that there are not billions of covid spike proteins floating around the human body when you get the vaccine.
- rrock 5y agoThe polyA tail is in the 3′ UTR (after the stop codon) and is not translated. It doesn’t appear in the final protein sequence. It’s also a fairly standard feature.
- q1w2 5y agoTo be clear, it's not translated into the final antibody, but it remains present in the vaccine, and hence in your body - it is what gives the vaccine structural stability in the body. ...and yes, it is standard - it is not covid-vaccine specific. This is all covered in This Week in Virology - one of the recent episodes about 3 months ago.