Thunderbird can do this with some configuration for replying to emails - set the pattern of the "Reply from this identity when delivery headers match" value of

Thunderbird can do this with some configuration for replying to emails - set the pattern of the "Reply from this identity when delivery headers match" value of Account Settings. It's not as good as the addon Virtual Identity used to be, but it works for me 85% of the time (see https://github.com/absorb-it/Virtual-Identity/issues/22#issuecomment-712382568 https://github.com/absorb-it/Virtual-Identity/issues/22#issu...). For new messages you still need an extension like Identity Chooser or to manually edit the from header before sending.