5 ms·
tl;dr - outside of a specific medical context, scholarly publications describe the term "sterilizing vaccine" including in online forums, as a FUD term by anti-
by eesmith 5y ago
tl;dr - outside of a specific medical context, scholarly publications describe the term "sterilizing vaccine" including in online forums, as a FUD term by anti-vaxxers.
walterbell previously used the term "sterilizing vaccine", and at https://news.ycombinator.com/item?id=28883691 https://news.ycombinator.com/item?id=28883691 commented "There's a stable definition in textbooks." / "If 2021 consumer media is offering variable definitions, Cui Bono?"
I decided to investigate.
Google Scholar reports about 176 uses of the phrase "sterilizing vaccine"; the infrequency suggests it is not a common phrase, especially given how it's sometimes given in quotes, like:
> Because of the ability of HIV to rapidly establish latent reservoirs and undergo immune escape, it has been proposed that an HIV vaccine will need to be a “sterilizing” vaccine, or a vaccine that prevents infection in the absence of an anamnestic response. To achieve sterilizing immunity, a vaccine needs to elicit persisting levels of Ab that are sufficient to block an incoming infection. - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019109/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019109/
Most of the references to "sterilizing" were either regarding HIV, or recent publications about COVID, but not all. Here's one for chlamydia:
> The holy grail is to produce a sterilizing vaccine that would completely prevent infection in the individual and hence also prevent transmission of infection to others. However, if 100% prevention of infection is not possible to achieve, then some consideration needs to be given to a vaccine that mainly prevents ascending infections that lead to disease pathology. In fact, one argument might be to focus on the disease pathology, as this is the major consequence of infection. - https://www.sciencedirect.com/science/article/pii/S0264410X13011110?casa_token=Dy8wL4JwEvoAAAAA:jswC0XbMXQ46NQlMe4SBpZjgI-gS8--jyN4oSHKg5zbfmir3qi5z-u8yH7yap9pAJloW0Z3M https://www.sciencedirect.com/science/article/pii/S0264410X1...
Do note that "sterilizing vaccine" is also used to describe (putative) sterility caused by vaccines . This is not some sort of recent '2021 consumer media' definition.
One is the 2008 publication "Sterilizing Vaccines or the Politics of the Womb: Retrospective Study of a Rumor in Cameroon" concerning "a rumor that public health workers were administering a vaccine to sterilize girls and women" - https://anthrosource.onlinelibrary.wiley.com/doi/pdfdirect/10.1525/maq.2000.14.2.159?casa_token=POrlp4RcTVAAAAAA:xegAkTBG9iY0livsZtZcQJncdHEwrrii7MZVQ4l1D0iIzlhetd1sqnIJdh7L2Wn3nGASQ3_5gUoXaA https://anthrosource.onlinelibrary.wiley.com/doi/pdfdirect/1... . Another is https://www.taylorfrancis.com/chapters/edit/10.4324/9781315128795-13/rumor-begets-rumor-pamela-feldman-savelsberg-flavien-ndonko-song-yang https://www.taylorfrancis.com/chapters/edit/10.4324/97813151... , also about the same rumor.
A third is "HPV Vaccine Representations on Online Discussion Forums in Romania" from 2013 :
> A subcategory of people postulated that the vaccine is promoted with the hidden intention to exterminate part of the population: “Some guys out there consider we are too many on this earth!…They want us dead.” (NS, 2009). They frequently mentioned words such as “genocide”, “Masonic vaccine”, “experiment”, “sterilizing vaccine” and they considered vaccination as “the biggest crime against humanity”.
A fourth is https://dergipark.org.tr/en/download/article-file/275883 https://dergipark.org.tr/en/download/article-file/275883 about reasons for why heads of family decide to not vaccinate their children against polio:
> Aşılamaya uyumsuz aile reislerinin OPA’nın ilk dozunun ne zaman olduğunu bilmedikleri, OPA’nın güvenli olmadığı ve infertiliteye sebep olabileceğine inandıkları gösterilmiştir (1). - https://dergipark.org.tr/en/download/article-file/275883?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=sv&_x_tr_pto=nui https://dergipark.org.tr/en/download/article-file/275883?_x_...
[Translation] "It has been shown that heads of families who do not comply with vaccination do not know when the first dose of OPA is, and they believe that OPA is not safe and may cause infertility (1)."
(This cites the Cameroon paper as previous precedent.)
And one is a non-scholarly report from the Baker Institute AnnualReport 2011-2012 on a vaccine to make dog sterile:
> The dream of a long term solution to pet overpopulation has remained unrealized, ... "Dogs are so reproductively efficient that it's hard to make an impact with spaying alone. A safe sterilizing vaccine for both males and females could rapidly reduce feral dog populations and significantly improve their welfare worldwide." - https://ecommons.cornell.edu/xmlui/bitstream/handle/1813/48299/Baker-Institute_AnnualReport_2011-2012.pdf?sequence=1 https://ecommons.cornell.edu/xmlui/bitstream/handle/1813/482...
Thus, it seems best to avoid the terms "sterilizing vaccines" and "non-sterilizing vaccines" 1) in a non-clinical forum, and 2) in a context where the more specific term adds nothing.
- walterbell 5y agoHow about a BBC article that avoids the term, but makes a similar point? https://www.bbc.com/news/health-58270098 https://www.bbc.com/news/health-58270098 > There is a whole different suite of antibodies (known as immunoglobulin As) in the nose and lungs, compared with those (immunoglobulin Gs) that we measure in the blood. The former is more important as a barrier to infection. Natural infection, because it is in the nose rather than a jab in the arm, may be a better route to those antibodies, and nasal vaccines are being investigated too. Or a July 2021 paper from academics advising UK SAGE, https://www.gov.uk/government/publications/long-term-evolution-of-sars-cov-2-26-july-2021 https://www.gov.uk/government/publications/long-term-evoluti... > Whilst we feel that current vaccines are excellent for reducing the risk of hospital admission and disease, we propose that research be focused on vaccines that also induce high and durable levels of mucosal immunity in order to reduce infection of and transmission from vaccinated individuals. This could also reduce the possibility of variant selection in vaccinated individuals. When a layperson hears the term "immunity", they often equate this term with their experience of a vaccine like the MMR vaccine, which is one and done, rather than monthly reductions of effectiveness, followed by semi-annual boosters. This paper explains one cause of the confusion, i.e. blood/serum vs nose/mucosal immunity, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733922/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733922/ > The mucosal immune system is the largest component of the entire immune system, having evolved to provide protection at the main sites of infectious threat: the mucosae. As SARS-CoV-2 initially infects the upper respiratory tract, its first interactions with the immune system must occur predominantly at the respiratory mucosal surfaces, during both inductive and effector phases of the response. However, almost all studies of the immune response in COVID-19 have focused exclusively on serum antibodies and systemic cell-mediated immunity including innate responses. A layperson can understand that a respiratory virus is first encountered in the nose, not their arm muscle. That's why recovery from Covid nasal infection provides nasal/mucosal immunity (i.e. prevention of infection via defenses in upper respiratory tract) and a muscle-injected vaccine provides symptom reduction after nasal infection, via blood/serum antibodies.
- eesmith 5y agoSure. Are you going to stop using the terms "non-sterilizing vaccine" and "sterilizing vaccine", outside of any publication you may make in a medical journal? > experience of a vaccine like the MMR vaccine, which is one and done No, it absolutely isn't! I have personal experience. I had to get mumps booster shot in college because of a local outbreak. https://www.cdc.gov/mumps/vaccination.html https://www.cdc.gov/mumps/vaccination.html points out under "Mumps Outbreaks Still Occur" that "As most people are not routinely exposed to mumps, there is less immunologic boosting" so "During a mumps outbreak, public health authorities might recommend an additional dose of MMR vaccine for people who belong to groups at increased risk for getting mumps." It also points out that mumps vaccinations require two shots, not "one and done". People are regularly advised to get a tetanus booster every 10 years. Which reminds me, my last one was 10 years ago. And some people get yearly flu shots.