From what I have read, following the topic for many years, the key is to have a (human) guide to help you if they see you heading in the wrong direction. Psyche

From what I have read, following the topic for many years, the key is to have a (human) guide to help you if they see you heading in the wrong direction. Psychedelics can be thought of as emotional amplifiers; feed them bad thoughts for too long and you get a runaway spiral to permanently scarring your emotional well being. The same, however is true for good thoughts, leading to euforia, transcendental thoughts, etc., which I guess is why many folks come back to do them again (once they have rebuilt whatever reserves are needed). What any one person may experience on the same dose of the same chemical may vary wildly though, I imagine due to the levels of other chemicals already in the body, and the current emotional state.