F-keys hardly, unless you are running programs written for DOS like emulators or badly ported apps written with Windows or Linux in mind that don't adhere to ma

F-keys hardly, unless you are running programs written for DOS like emulators or badly ported apps written with Windows or Linux in mind that don't adhere to macOS keyboard shortcuts. But the brightness and media/volume keys (which is the default function of the keys) I use all the time.