ML will depend on whether or not whatever ML platform you are using has a back end for the M1 GPU. I suspect that the M1 GPU's would have at least a OpenGL and

ML will depend on whether or not whatever ML platform you are using has a back end for the M1 GPU. I suspect that the M1 GPU's would have at least a OpenGL and a Metal driver so I presume most games that worked on macOS previously would work on the M1.