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Chimeric antigen receptor (CAR) T-cell therapy is a way to get immune cells called T cells (a type of white blood cell) to fight cancer by changing them in the
by adolph 5y ago
Chimeric antigen receptor (CAR) T-cell therapy is a way to get immune cells called T cells (a type of white blood cell) to fight cancer by changing them in the lab so they can find and destroy cancer cells. CAR T-cell therapy is also sometimes talked about as a type of cell-based gene therapy, because it involves altering the genes inside T cells to help them attack the cancer.
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In CAR T-cell therapies, T cells are taken from the patient's blood and are changed in the lab by adding a gene for a man-made receptor (called a chimeric antigen receptor or CAR). This helps them better identify specific cancer cell antigens. The CAR T cells are then given back to the patient.
https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/car-t-cell1.html https://www.cancer.org/treatment/treatments-and-side-effects...
Right now this is done in a very personalized and labor intensive way. I think the thought is mRNA is potentially a gigafactory compared to artisanal methods.
- anonfornoreason 5y agoThey also can only target cancers that have specific markers that are unique to the cancer and not normal cells, lest the treatment kill non cancer cells. Early experiments here did lead to patient deaths (in advanced already going to die cancer patients). Not all cancers have these unique markers so this therapy only works on a few types,m. Fantastic podcast covering topic by interviewing the father of these therapies: https://youtu.be/pVMl0LgdnOU https://youtu.be/pVMl0LgdnOU Podcast available on Apple podcasts etc. The Drive episode 177. can't recommend enough.