He's saying that none of these studies have shown in the real world that ivermectin effects TMPRSS2. And I've been trying to have an honest discussion from the

He's saying that none of these studies have shown in the real world that ivermectin effects TMPRSS2. And I've been trying to have an honest discussion from the beginning. I said I'd failed to find what you were claiming, but tried to make it clear that I was listening if you did have some evidence. Luckily you did, but analyte123 pointed out it was weak. This paper seems to to be a survey of other papers so doesn't actually provide any new evidence itself. It also has a few grammar issues which makes me more skeptical of it, but whatever. The claim made as I understand it is that there is only very weak evidence that `ivermectin` might effect `TMPRSS2` (aka computer models). Since we've done randomized controlled trials we can be fairly confident that ivermectin doesn't work to treat covid. The best evidence I've heard of for it working came from cell cultures where at very high concentrations it was able to prevent covid from entering cells so maybe the mechanism there even is related to TMPRSS2, but I'm just not really sure of what discussion you were expecting. Your comment read to me like you see this as vindication that ivermectin is likely to be an effective drug, when it sounds like TMPRSS2 has been consistently targeted as a treatment for covid by a number of different drugs and you've still only shown at best weak evidence that ivermectin even effects it