Good article, a litrevew of sorts focusing on long term immunity (B cell behavior) and multiple infection events. Dissapointingly, studying only infection + vac

Good article, a litrevew of sorts focusing on long term immunity (B cell behavior) and multiple infection events. Dissapointingly, studying only infection + vaccine and vaccine + vaccine (+ booster) sequences. Looking forward further work to tackle vaccine + infection and infection + infection cases. A couple bits that caught my eye (i.e. reinforced my biases), though the whole article is well worth a read. ----- > The team isolated hundreds of memory B cells — each making a unique antibody — from people at various time points after infection and vaccination. Natural infection triggered antibodies that continued to grow in potency and their breadth against variants for a year after infection, whereas most of those elicited by vaccination seemed to stop changing in the weeks after a second dose. Memory B cells that evolved after infection were also more likely than those from vaccination to make antibodies that block immune-evading variants such as Beta and Delta. ----- > As breakthrough infections caused by the Delta variant stack up, researchers including Nussenzweig are keen to study the immunity in people who were infected after their COVID-19 vaccinations, rather than before. An individual’s first exposure to influenza virus biases their responses to subsequent exposures and vaccinations — a phenomenon called original antigenic sin — and researchers want to know if this occurs with SARS-CoV-2.