Major drawbacks are closed-source applications intended for RedHat. These might work with some kind of binary emulation, but the vendor will never support it.

Major drawbacks are closed-source applications intended for RedHat. These might work with some kind of binary emulation, but the vendor will never support it. My focus would be database. Microsoft's binary ODBC libraries and Oracle Instant Client are Linux binaries. FreeTDS and Oracle SQLcl/JDBC are options on a BSD, but there are drawbacks, as there likely would be with any binary packages. I know that both RedHat and Oracle will migrate an installed CentOS to their platforms (RedHat does it more violently, by replacing every installed package). Alma & Rocky might also be migration options.