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Fecal Transplants May Reverse Brain Aging in Mice

57 points by colinprince 5y ago

kruxigt 5y ago
Read face transplants. Was confused for a while..
JulianMorrison 5y ago
Eat shit and don't die?
catlikesshrimp 5y ago
How and Why is this a top story? The only relation I can imagine is that the second most numerous group of neurons, first being the central nervous system, is located in the gastrointestinal tract.
- echelon 5y ago
  It changes the gut microbiome, which may change expression and concentration of serum molecules such as lipoproteins. Lipoprotein complexes have been shown to extravasate into the brain tissues and may lead to inflammation and dysfunction. There are a whole host of mechanisms that could be involved, and we're only now beginning to tease this apart.
- RedBeetDeadpool 5y ago
  I mean isn't the concept fascinating? If you were guaranteed an extra year of life after stuffing a pint of little timmy's homemade rocky road ice cream up your butt, would you do it?
  - Fezzik 5y ago
    I’m in your court - the fecal matter transplant (FMT) thing has always been fascinating to me. On top of additional years, what if an FMT could just make your years better: it could make it easier to lose weight, or ease depression, or positively alter cognitive abilities… a person’s ability to process nutrients appropriately seems like it could have immense positive benefits. And a healthy gut biome seems important in that regard.
in_mice 5y ago
Blood transfusions were already the hip thing to do in SV, now it's gonna be fecal transplants from younger individuals.
- bell-cot 5y ago
  Somehow, I'm envisioning a new boarding school for extremely gifted small children, with suspiciously low fees paid by the parents...
- LurkingPenguin 5y ago
  Look for the first Shitfer Brains location in Palo Alto to open in Q1 2022. Stanford students (undergrads only) interested in a quick and easy side hustle are welcome to apply to become a stool donor at https://www.shitfer.io/stool-associates https://www.shitfer.io/stool-associates
RcouF1uZ4gsC 5y ago
> They started by taking fecal samples from 3- to 4-month-old mice—young adult mice, by human standards—and fed the slurry to geriatric 20-month-old rodents using a feeding tube twice a week. How similar is the brain aging in a 20 month old mouse to the brain aging in a 70/80/90 year old human? I think one of the biggest errors when looking at animal aging studies is assuming thinking that there is a linear relationship (for example 1 human year is 7 dog years, etc).
webmobdev 5y ago
So gut microbes / ProBiotics - but they just don't know yet which ones are the good and bad ones and so recommend you get everything and let your body sort it out ...
m0zg 5y ago
May I suggest an excellent, high value human test subject for brain aging reversal? /s
- timonoko 5y ago
  Lets go Brandon.
uzakov 5y ago
This is straight from South Park https://en.wikipedia.org/wiki/Turd_Burglars https://en.wikipedia.org/wiki/Turd_Burglars https://www.youtube.com/watch?v=ENEBRFOVuXI https://www.youtube.com/watch?v=ENEBRFOVuXI
- 1cvmask 5y ago
  That was the first thing that came to my mind when I saw the headline. Some of their shows are often seen as absurd and then they become mainstream reality years later. Sort of like some of the old Monty Python works. For example there is the skit where they talk about fractious Judean (insert Israeli) politics and men giving birth: https://www.youtube.com/watch?v=WboggjN_G-4 https://www.youtube.com/watch?v=WboggjN_G-4 https://www.youtube.com/watch?time_continue=9&v=sFBOQzSk14c&feature=emb_logo https://www.youtube.com/watch?time_continue=9&v=sFBOQzSk14c&...
nirav72 5y ago
First there were the blood boys. Now this. Rich people are going to need people around just to increase their longevity. Too bad the show Silicon Valley ended. This would've been perfect for an episode.
desktopninja 5y ago
Switching context to dogs, there are plenty reasons why dogs eat other dogs poop but maybe there is something to this. Often noticed older dogs like to eat younger dog poop. Its almost instinctive too.

57 points by colinprince 5y ago

kruxigt 5y ago

Read face transplants. Was confused for a while..

JulianMorrison 5y ago

Eat shit and don't die?

catlikesshrimp 5y ago

How and Why is this a top story? The only relation I can imagine is that the second most numerous group of neurons, first being the central nervous system, is located in the gastrointestinal tract.

echelon 5y ago
It changes the gut microbiome, which may change expression and concentration of serum molecules such as lipoproteins. Lipoprotein complexes have been shown to extravasate into the brain tissues and may lead to inflammation and dysfunction. There are a whole host of mechanisms that could be involved, and we're only now beginning to tease this apart.
RedBeetDeadpool 5y ago
I mean isn't the concept fascinating? If you were guaranteed an extra year of life after stuffing a pint of little timmy's homemade rocky road ice cream up your butt, would you do it?
- Fezzik 5y ago
  I’m in your court - the fecal matter transplant (FMT) thing has always been fascinating to me. On top of additional years, what if an FMT could just make your years better: it could make it easier to lose weight, or ease depression, or positively alter cognitive abilities… a person’s ability to process nutrients appropriately seems like it could have immense positive benefits. And a healthy gut biome seems important in that regard.

in_mice 5y ago

Blood transfusions were already the hip thing to do in SV, now it's gonna be fecal transplants from younger individuals.

bell-cot 5y ago
Somehow, I'm envisioning a new boarding school for extremely gifted small children, with suspiciously low fees paid by the parents...
LurkingPenguin 5y ago
Look for the first Shitfer Brains location in Palo Alto to open in Q1 2022. Stanford students (undergrads only) interested in a quick and easy side hustle are welcome to apply to become a stool donor at https://www.shitfer.io/stool-associates https://www.shitfer.io/stool-associates

RcouF1uZ4gsC 5y ago

> They started by taking fecal samples from 3- to 4-month-old mice—young adult mice, by human standards—and fed the slurry to geriatric 20-month-old rodents using a feeding tube twice a week. How similar is the brain aging in a 20 month old mouse to the brain aging in a 70/80/90 year old human? I think one of the biggest errors when looking at animal aging studies is assuming thinking that there is a linear relationship (for example 1 human year is 7 dog years, etc).

webmobdev 5y ago

So gut microbes / ProBiotics - but they just don't know yet which ones are the good and bad ones and so recommend you get everything and let your body sort it out ...

m0zg 5y ago

May I suggest an excellent, high value human test subject for brain aging reversal? /s

timonoko 5y ago
Lets go Brandon.

uzakov 5y ago

This is straight from South Park https://en.wikipedia.org/wiki/Turd_Burglars https://en.wikipedia.org/wiki/Turd_Burglars https://www.youtube.com/watch?v=ENEBRFOVuXI https://www.youtube.com/watch?v=ENEBRFOVuXI

1cvmask 5y ago
That was the first thing that came to my mind when I saw the headline. Some of their shows are often seen as absurd and then they become mainstream reality years later. Sort of like some of the old Monty Python works. For example there is the skit where they talk about fractious Judean (insert Israeli) politics and men giving birth: https://www.youtube.com/watch?v=WboggjN_G-4 https://www.youtube.com/watch?v=WboggjN_G-4 https://www.youtube.com/watch?time_continue=9&v=sFBOQzSk14c&feature=emb_logo https://www.youtube.com/watch?time_continue=9&v=sFBOQzSk14c&...

nirav72 5y ago

First there were the blood boys. Now this. Rich people are going to need people around just to increase their longevity. Too bad the show Silicon Valley ended. This would've been perfect for an episode.

desktopninja 5y ago

Switching context to dogs, there are plenty reasons why dogs eat other dogs poop but maybe there is something to this. Often noticed older dogs like to eat younger dog poop. Its almost instinctive too.