3 ms·
Sure that's possible. But it's also overweighting potential harms in an imaginary future scenario over potential benefits today. One can come up with other imag
by krrrh 5y ago
Sure that's possible. But it's also overweighting potential harms in an imaginary future scenario over potential benefits today. One can come up with other imaginary scenarios, not to be too dramatic, but the same arguments were likely made against Semmelweis [0] when he promoted hand washing before delivering babies, or the people who discovered the ketogenic diet helped manage epilepsy in the 1920s. [1]
Scientific progress has often been speculative and messy. The few thousand people with ApoE4 genes who read his book and then actually commit to time-restricted feeding, exercising 4 times a week, sleeping 8 hours, and semi-ketogenic diets might have better outcomes a decade from now than those who don't. If that discourages another few tens of thousands of people from taking a potential blockbuster drug in the early years after its release, fine. It's worth the natural experiment to find out because millions of people are not getting much relief from current treatments [2]. This is even more true given that Alzheimer's isn't communicable.
[0] https://en.wikipedia.org/wiki/Ignaz_Semmelweis https://en.wikipedia.org/wiki/Ignaz_Semmelweis
[1] Which is lately experiencing a renaissance see https://charliefoundation.org https://charliefoundation.org
[2] Official bodies also continue to approve therapies with evidence that appears inconclusive with a higher degree of certainty than Bredeson's protocol. https://hub.jhu.edu/2021/06/21/fda-aduhelm-approval/ https://hub.jhu.edu/2021/06/21/fda-aduhelm-approval/