3 ms·
What are novel biologics?
by amatic 5y ago
What are novel biologics?
- datameta 5y agoMedication that is past what is considered "large molecule" and in the size and complexity ballpark of proteins. These need to be injected as opposed to taken orally as they're too large to enter the bloodstream otherwise. There is a whole search space out there for medication of this class and we're only just getting started. It's (loosely) like finding out what is possible with a 100MB program vs a 50KB one.
- dm3 5y agoThis is very interesting. Are there any books you'd recommend on the topic which would explain the directions pharmaceutical science is heading towards to a layman?
- datameta 5y agoI'm not currently aware of a book on the subject, but would also like to read a compilation of the cutting edge. I am relaying what I know from tangentially following advances my peers participate in filtered through my former chemistry+bioinformatics background. Here is some more info on considerations to be had for near-future breakthroughs in the oral administration route. The key is in preserving the biologic structure long enough for it to reach the intestine where, in contrast to the stomach, it would be able to enter the bloodstream with the aid of agents that enhance permeability. https://otd.harvard.edu/explore-innovation/technologies/oral-delivery-of-biologics https://otd.harvard.edu/explore-innovation/technologies/oral... Edit: The field of cheminformatics is currently utilizing machine learning to help discover novel drugs in the various search spaces, such as that of kinase inhibitors. They have the ability to function in a multi-target regime. That is, there exist drugs that can be effective for several pathologies.