3 ms·

Anti-androgens and GnRH agonists like Spironolactone, Cyproterone Acetate, Goserelin Acetate, Bicalutamide to name a few. Also to a lesser extent 5α-reductase i

Anti-androgens and GnRH agonists like Spironolactone, Cyproterone Acetate, Goserelin Acetate, Bicalutamide to name a few. Also to a lesser extent 5α-reductase inhibitors like finasteride (Propecia) which only suppress the more potent dihydrotestosterone. All of these work by suppressing androgen production (mostly testosterone and dihydrotestosterone), this will suppress most of the male libido. While they don't remove the ability to get an erection if you try, they will prevent the hormonal lead-up that would normally lead to one. You'll likely stop thinking about sex entirely, there won't be much of a drive. GnRH agonists like Goserelin Acetate (zolodex) are highly effective, spironolactone is very weak and a potent diuretic. On the downside... an adult human body expects to have a dominant sex hormone, either testosterone or oestrogen, and a lot of things hang off this. For one, initial breast growth is inhibited by testosterone, so you will likely develop gynecomastia (unwanted breast development). Your body hair will reduce, though facial hair is mostly unaffected, and your skin will become softer. Long term you are at increased risk of developing osteoporosis, and your testes and genitals will shrink. Sperm count and viability will reduce, though for some people this is recoverable. It will halt any male pattern baldness though. Most of these drugs are used for treatment of prostate and testicular cancer, so their effects are well known.

ehPReth 5y ago
Is that what they use for “chemical castration”?
- xyzzy21 5y ago
  Yes, sometimes. I'd recommend that any man thinking about taking these for ANY REASON (including transitioning) have his T levels measured first - Low T is more likely to cause adverse behaviors and mental issues than high T (contrary to the "roid rage" hypothesis of "male toxicity" BS). Roid rage can be a thing but it's more complex than simply having too much T - it's a dynamical system so it's very much like getting a sugar high and then insulin shock afterwards: you will rebound from high T intake to very low intake and that better explains most of roid rage.
- sitharus 5y ago
  Where I live high doses of cyproterone acetate have been used for chemical castration (>200mg), but at these levels there's a chance of developing benign brain tumours, so they try not to do this. I think zolodex is also used in this manner, and it's more effective since it's a long-lasting implant rather than a daily pill. In both cases they're not 100% effective, different people respond differently.
faeyanpiraat 5y ago
Do you happen to be a doctor/scientist? I’ve had an unbelievable experience which I’m looking for a scientific explanation to / trying to replicate, but I’d rather not share publicly. Is there a way to get in contact with you outside hn?
- sitharus 5y ago
  Alas no, just someone on those medications so I've done a lot of research in to them.

ehPReth 5y ago

Is that what they use for “chemical castration”?

xyzzy21 5y ago
Yes, sometimes. I'd recommend that any man thinking about taking these for ANY REASON (including transitioning) have his T levels measured first - Low T is more likely to cause adverse behaviors and mental issues than high T (contrary to the "roid rage" hypothesis of "male toxicity" BS). Roid rage can be a thing but it's more complex than simply having too much T - it's a dynamical system so it's very much like getting a sugar high and then insulin shock afterwards: you will rebound from high T intake to very low intake and that better explains most of roid rage.
sitharus 5y ago
Where I live high doses of cyproterone acetate have been used for chemical castration (>200mg), but at these levels there's a chance of developing benign brain tumours, so they try not to do this. I think zolodex is also used in this manner, and it's more effective since it's a long-lasting implant rather than a daily pill. In both cases they're not 100% effective, different people respond differently.

faeyanpiraat 5y ago

Do you happen to be a doctor/scientist? I’ve had an unbelievable experience which I’m looking for a scientific explanation to / trying to replicate, but I’d rather not share publicly. Is there a way to get in contact with you outside hn?

sitharus 5y ago
Alas no, just someone on those medications so I've done a lot of research in to them.