Over the years, I tested multiple options, and currently, I'm using NixOS declarative containers. It requires more work to create a new environment than with ni

Over the years, I tested multiple options, and currently, I'm using NixOS declarative containers. It requires more work to create a new environment than with nix-shell, but in my experience, this is not a bottleneck. With some setup, you can even run graphical applications inside containers. I've written more about this and other approaches on my blog: https://msucharski.eu/posts/application-isolation-nixos-containers/ https://msucharski.eu/posts/application-isolation-nixos-cont... if you are interested. It is pretty specific to my needs, so it may not work for you. Regarding the Windows: after playing with GPU-passthrough, I came back to dual-boot. It is more reliable because you are less likely to run into some hardware quirk.